| Edit | RomName | Publisher | Year | Country | PlatForm | Cheat | GenMSX |
 | SCC PCM Demo 1 | Manuel Pazos | 2007 |  |  | | |
| SCC PCM Demo 2 | Manuel Pazos | 2007 | | | | |
| SCC PCM Replayer 1 | Artrag | 2007 |  | | | |
| SCC PCM Replayer 2 | Artrag | 2008 | | | | |
| SCC fake cartridge | Konami | 2003 |  | | | |
| SCC+ fake cartridge | Konami | 2003 | | | | |
| SHM | NAMCO | 1989 | | | |  |
| SHMUP! | Imanok | 2013 | | | | |
| SKULLrs | Digiconcrete | 2017 | | | | |
| Saimazoom | Karoshi Corporation | 2005 | | | | |
| Sakhr Dictionary | Al Alamiah | 1987 |  | | | |
| Sakhr Logo | Al Alamiah | 1987 | | | | |
| Salamander - Operation X | Konami | 1987 | | | | |
| Sammy Lightfoot | Sierra On Line | 1983 |  |  | | |
| Sangokushi 1 - Romance Of Three Kingdoms - MSX1 Version | KOEI | 1986 | | | | |
| Sangokushi 1 - Romance Of Three Kingdoms - MSX2 Version | KOEI | 1988 | |  | | |
| Sangokushi 2 | KOEI | 1991 | | | | |
| Sasa | Mass Tael | 1983 |  | | | |
| Satujinkurakubu - Murder Club | Microcabin | 1988 | | | | |
| Saurus Land | Nippon Columbia / Colpax / Universal | 1982 | | | | |
| Scarlet 7 | Soft Pro | 1986 | | | | |
| Schlange CV Demo | Philipp Klaus Krause | 2005 |  | | | |
| Scion | Seibu Denshi | 1985 | | | | |
| Scope On | ASCII | 1983 | | | | |
| Scramble Eggs | Ample Software | 1983 | | | | |
| Scramble Formation | TAITO | 1987 | | | | |
| Screen 5 | Yukio | 2009 |  | | | |
| Screen Copy | Epson | 1985 | | | | |
| Scroll Demo | PD | 200x | | | | |
| Scroll Demo | Daniel Bienvenu | 2004 | | | | |
| Sea Horse | Al Alamiah | 1984 | | | | |
| Sea Hunter | Spectravideo | 1984 | | | | |
| Search for the Stolen Crown Jewels | Philipp Klaus Krause | 2005 | | | | |
| Search for the Stolen Crown Jewels 2 | Philipp Klaus Krause | 2007 | | | | |
| Sebaweh 1 | Al Alamiah | 1985 | | | | |
| Sebaweh 2 | Al Alamiah | 1985 | | | | |
| Secret Word | Al Alamiah | 1985 | | | | |
| Sector 88 | Kai Magazine | 2016 | | | | |
| Sector Alpha | Spectravideo | 1983 | | | | |
| Seiken Acho - Kung-Fu Master Taekwondo | IREM / ASCII | 1985 | | | | |
| Seikima 2 Special | Tetsuji | 1987 | | | | |
| Seleniak | Mark II | 2004 | | | | |
| Senjyo | Tehkan | 1984 | | | | |
| Senjyo no Ookami - Commando | Capcom / ASCII | 1985 | | | | |
| Sets | Al Alamiah | 1985 | | | | |
| Sewer Sam | Interphase | 1984 | | | | |
| Sewer Sam | Interphase | 1984 | | | | |
| Shanghai | System Soft | 1987 | | | | |
| Shater Hassan | Barq | 1987 | | | | |
| Shift | Infinite | 2009 |  | | | |
| Shigun | Nippon Dexter | 1987 | | | | |
| Shouganai | Paxanga Soft | 2013 | | | | |
| Shougi Meijin | Soft Pro | 1985 | | | | |
| Shougi Sinan 1 | Microcabin | 1985 | | | | |
| Shougi Sinan 2 | Pony Canyon | 1988 | | | | |
| Shout Match | Fun Project | 1987 | | | | |
| Sideview Attackers | N.Komabune | 1994 | | | | |
| Simple ASM 1.0 | Coral Sea | 1984 | | | | |
| Simple Screen Show | Daniel Bienvenu | 2001 | | | | |
| Sinbad | Casio | 1986 | | | | |
| Sink King | Guzuta Raster Leisure | 2004 | | | | |
| Sir Lancelot | Xonox | 1983 | | | | |
| Sirius' Squish'em | Sirius / ASCII | 1983 | | | | |
| Sirius' Turmoil | Sirius / ASCII | 1983 | | | | |
| Siryousensen - War Of The Dead | Victor | 1987 | | | | |
| Skate Air | Yermani Soft | 2006 | | | | |
| Ski Command | Casio | 1984 | | | | |
| Skiing | Telegames | 1986 | | | | |
| Skooter | The Bytebusters | 1987 | | | | |
| Sky Galdo | MagicalZoo | 1986 | | | | |
| Sky Jaguar | Konami | 1984 | | | | |
| Sky Jaguar | Konami | 1984 | | | | |
| Slapshot | Indescomp | 1985 | | | | |
| Slender - The Camping | Pentacour | 2013 | | | | |
| Slime Center | N.I | 2017 | | | | |
| Slither | Coleco | 1983 | | | | |
| Slurpy | Xonox | 1984 | | | | |
| Smash | Daniel Bienvenu | 2004 | | | | |
| Smurf Paint 'N' Play Workshop | Coleco | 1984 | | | | |
| Smurf Rescue In Gargamel's Castle | Coleco | 1982 | | | | |
| Smurf Rescue In Gargamel’s Castle | Coleco | 1982 | | | | |
| Smurfs Save the Day | Coleco | 198X | | | | |
| Snail Maze | Karoshi Corporation | 2004 | | | | |
| Snake-It | The Bytebusters | 1986 | | | | |
| Snoopy Town | AG Software | 2005 | | | | |
| Snow Climber | DVIK & Joyrex productions | 2008 | | | | |
| Snowclimber | Joyrex | 2003 | | | | |
| Sofia | Radio Wave Newspaper Publisher Company | 1987 | | | | |
| Sokoban | ASCII / Thinking Rabbit | 1988 | | | | |
| Solitario | Nitrofurano | 2002 |  | | | |
| Sony Test Cartridge | Sony | 19xx | | | | |
| Soukoban | ASCII / Thinking Rabbit | 1984 | | | | |
| Soukoban | Qnix | 1984 |  | | | |
| Soukoban Pocket Edition | Karoshi Corporation | 2004 | | | | |
| Sound FX Vol 1 | Daniel Bienvenu | 2000 | | | | |
| Sound FX Vol 2 | Daniel Bienvenu | 2000 | | | | |
| Sp8 Invaders | Dioniso | 2009 | | | | |
| Space Arithmetic | Al Alamiah | 1985 | | | | |
| Space Buster | Aackosoft / The Bytebusters | 1985 | | | | |
| Space Camp | Pack-In-Video | 1986 | | | | |
| Space Caverns | Scott Huggins | 2004 | | | | |
| Space Crussader | Yermani Soft | 2005 | | | | |
| Space Fury | Coleco | 1983 | | | | |
| Space Hunter | Guy Foster | 2005 | | | | |
| Space Invader | TAITO | 1985 | | | | |
| Space Invaders Collection | TAITO | 2002 | | | | |
| Space Invasion | John Dondzila | 1998 | | | | |
| Space Manbow | Konami | 1989 | | | | |
| Space Maze Attack | HAL Laboratory | 1983 | | | | |
| Space Panic | Coleco | 1983 | | | | |
| Space Scape ! | FarAwayCorporation | 2008 | | | | |
| Space Trainer | Daniel Bienvenu | 2005 | | | | |
| Space Trouble | HAL Laboratory | 1984 | | | | |
| Space Walk | Mastertronic | 1987 | | | | |
| Space Way | German Gomez Herrera | 2008 | | | | |
| Sparkie | Konami | 1983 | | | | |
| Spaz Attak Teaser | Howard Uman | 2006 | | | | |
| Special Screen Mode | Daniel Vik | 2006 | | | | |
| Spectank Demo | Daniel Bienvenu | 2000 | | | | |
| Spectron | Spectravideo | 1983 | | | | |
| Spelunker | IREM | 1986 | | | | |
| Spelunker | Brain Games | 2017 | | | | |
| Sphere Redux | Impulse9 | 2007 | | | | |
| Spider, The | Hudson Soft / Japanese Softbank | 1983 | | | | |
| Sport Racer | German Gomez Herrera | 2006 | | | | |
| Spread Sheet | Kuma Computers | 1984 | | | | |
| Spy Hunter | Coleco | 1984 | | | | |
| Spy Vs Spy II | First Star Software | 1986 | | | | |
| Square Dancer | T&ESOFT | 1984 | | | | |
| Squares! | Harvey deKleine | 2006 | | | | |
| Squish'em Featuring Sam | Interphase | 1984 | | | | |
| St. Valentine's Day | PD | 2002 | | | | |
| Stan, the dreamer | The Pets Mode | 2013 | | | | |
| Star Battle | German Gomez Herrera | 2008 | | | | |
| Star Blazer | Starcraft | 1985 | | | | |
| Star Command | ASCII | 1983 | | | | |
| Star Demo | PD | 200x | | | | |
| Star Force | Tehkan | 1985 | | | | |
| Star Fortress by | John Dondzila | 1997 | | | | |
| Star Soldier | Hudson Soft | 1986 | | | | |
| Star Trap | Jast | 1987 | | | | |
| Star Trek Strategic Operations Simulator | Coleco | 1984 | | | | |
| Star Virgin | Pony Canyon | 1988 | | | | |
| Star Wars The Arcade Game | Parker Brothers | 1984 | | | | |
| Starry Nights 3 Demo | Guy Foster | 2004 | | | | |
| Starry Nights Demo | Guy Foster | 2005 | | | | |
| Starship Simulator | NEXA | 1984 | | | | |
| Steamroller | Activision | 1984 | | | | |
| Step Up | Marvel Soft/Takara | 1983 | | | | |
| Stepper | ASCII | 1985 | | | | |
| Stone of Wisdom, The | Casio | 1986 | | | | |
| Strange Loop | Nippon Dexter | 1987 | | | | |
| Strategic Mars | dB-SOFT | 1989 | | | | |
| Stratos | CEZ Games Studio | 2004 | | | | |
| Stratos 2 | CEZ Games Studio | 2005 | | | | |
| StrayCat | Imanok | 2009 | | | | |
| Street Master | Zemina | 1991 | | | | |
| Strike It! | Telegames | 1986 | | | | |
| Stubby Demo | Yannick Proulx | 2001 | | | | |
| SubRoc | Coleco | 1983 | | | | |
| Subacuatic | RELEVO Videogames | 2012 | | | | |
| Sudoku | DVIK & Joyrex productions | 2006 | | | | |
| Suikoden | KOEI | 1989 | | | | |
| Suparobo | Mass Tael | 1984 | | | | |
| Super Action Baseball | Coleco | 1983 | | | | |
| Super Action Controller Test Cartridge | Nuvatec | 1983 | | | | |
| Super Action Football | Coleco | 1984 | | | | |
| Super Action Soccer | Coleco | 1984 | | | | |
| Super Billiards | HAL Laboratory | 1984 | | | | |
| Super Bio Man 4 | Segye-ro Electronics | 19xx | | | | |
| Super Boy I | Zemina | 1989 | | | | |
| Super Boy II | Zemina | 1989 | | | | |
| Super Boy III | Zemina | 1991 | | | | |
| Super Bros. World 1 | Clover | 1991 | | |  | |
| Super Bubble Bobble | Zemina | 1988 | | | | |
| Super Cobra | Konami | 1983 | | | | |
| Super Cobra | Parker Brothers | 1983 | | | | |
| Super Columns | Hi-Com Co Ltd | 1990 |  | | | |
| Super Cross Force | Spectravideo | 1983 | | | | |
| Super Cross Force | Spectravideo | 1983 | | | | |
| Super Daisenryaku | Microcabin | 1988 | | | | |
| Super Donkey Kong | Coleco | 1983 | | | | |
| Super Donkey Kong Junior | Coleco | 1983 | | | | |
| Super Drinker | Ample Software | 1983 | | | | |
| Super Golf | Comtec | 1984 | | | | |
| Super Laydock - Mission Striker | T&ESOFT | 1987 | | | | |
| Super Lode Runner | IREM | 1987 | | | | |
| Super Mario World | Daemos et al. | 2016 | | | | |
| Super Monitor | Emiiru | 1985 | | | | |
| Super Pachinko | Nippon Columbia / Colpax / Universal | 1985 | | | | |
| Super Pierrot | Nippon Columbia / Colpax / Universal | 1987 | | | | |
| Super Rambo Special | Pack-In-Video | 1986 | | | | |
| Super Runner | Pony Canyon | 1987 | | | | |
| Super Sketch Sketch-Master | Personal Peripherals | 1984 | | | | |
| Super Snake | HAL Laboratory | 1983 | | | | |
| Super Soccer | Sony / Takara | 1985 | | | | |
| Super Swangi - Super Altered Beast | Clover | 1990 | | | | |
| Super Synth | Cross Media Soft | 1984 | | | | |
| Super Tennis | Takara | 1984 | | | | |
| Super Tripper | Indescomp | 1985 | | | | |
| Super Tritorn | XAIN / Sein | 1986 | | | | |
| Superpong Demo | PD | 2000 | | | | |
| Suru'ba | Thinking Rabbit | 1983 | | | | |
| Sweet Acorn | TAITO | 1984 | | | | |
| Swing | Compile | 1985 | | | | |
| Sword And The Sorcerer, The | Coleco | 1983 | | | | |
| Synthe Saurus 1.1 | BIT2 | 1988 | | | | |