| Edit | RomName | Publisher | Year | Country | PlatForm | Cheat | GenMSX |
 | ZERO and the Castle of Infinite Sadness | Dioniso | 2014 |  |  | | |
| Zaider - Battle of Peguss | Cosmos computer | 1986 |  | | |  |
| Zambeze | Degora | 2006 | | | | |
| Zanac A.I. | Compile | 1986 | | | | |
| Zanac A.I. - 2nd Version | Compile | 1987 | | | | |
| Zanac-Ex | Compile | 1986 | |  | | |
| Zaxxon | Sega | 1985 | | | | |
| Zaxxon | Coleco | 1982 |  |  | | |
| Zemina 30 Multi Rom Pack | Zemina | 19xx |  | | | |
| Zen Assembler | Avalon Software | 1986 |  | | | |
| Zenji | Activision / Pony Canyon | 1984 | | | | |
| Zenji | Activision | 1984 | | | | |
| Zevimodoki | GWʼs-Workshop | 2017 | | | | |
| Zexas Limited | dB-SOFT | 1985 | | | | |
| Zippy Race (aka Traverse USA) | IREM/Sega / hap | 2007 | | | | |
| Zoids | Toshiba-EMI | 1988 | | | | |
| Zombie Hunter | Hi-Score | 1989 | | | | |
| Zombie Incident | Nenefranz | 2012 | | | | |
| Zombie Near | Oscar Toledo Gutiérrez | 2011 | | | | |
| Zone TNT | AG Software | |  | | | |
| Zone Terra | Quadrivium | 1994 | | | | |
| Zoom 909 | Sega | 1985 | | | | |
| Zukkoke Yajikita Onmitsudoutyuu | HAL Laboratory | 1987 | | | | |