| Zipper | Kuma Computers | 1985 |  |  | 1 |
| Z | Cobinee | 2019 |  | | 3 |
| Zaider - Battle of Peguss | Cosmos computer | 1986 | | | 4 |
| Zambeze | Degora | 2006 |  | | 2 |
| Zanac A.I. | Compile | 1986 | | | 8 |
| Zanac A.I. - 2nd Version | Compile | 1987 | | | 5 |
| Zanac-Ex | Compile | 1986 | |  | 12 |
| Zaxxon | Sega | 1985 | | | 7 |
| Zen Assembler | Avalon Software | 1986 |  | | 1 |
| Zenji | Activision / Pony Canyon | 1984 | | | 3 |
| Zexas Limited | dB-SOFT | 1985 | | | 4 |
| Zippy Race (aka Traverse USA) | IREM/Sega / hap | 2007 | | | 1 |
| Zoids | Toshiba-EMI | 1988 | | | 3 |
| Zombie Hunter | Hi-Score | 1989 | | | 4 |
| Zoom 909 | Sega | 1985 | | | 2 |
| Zukkoke Yajikita Onmitsudoutyuu | HAL Laboratory | 1987 | | | 5 |
| Zombie Near | Oscar Toledo Gutiérrez | 2011 | | | 2 |
| Zombie Incident | Nenefranz | 2012 | | | 4 |
| Zone TNT | AG Software | 2011 |  | | 1 |
| ZERO and the Castle of Infinite Sadness | Dioniso | 2014 | | | 3 |
| Zevimodoki | GWʼs-Workshop | 2017 | | | 2 |
| Zone Terra | Quadrivium | 1994 | | | 1 |
| Zaxxon | Coleco | 1982 |  |  | 4 |
| Zenji | Activision | 1984 | | | 1 |
| Zemina 30 Multi Rom Pack | Zemina | - |  | | 1 |
| Zeta 2000 | Pixel | 1985 | | | 1 |
| Zakil Wood Remake | NataliaPC | 2019 | | | 4 |
| z80rogue | Oscar Toledo Gutiérrez | 2019 | | | 1 |
| Zoot | Bug-Byte Software | 1986 | | | 1 |
| Zakil Wood | Mr. Micro | 1985 | | | 2 |
| Zap | Unknown | - | | | 1 |
| Zexas | dB-SOFT | 1984 | | | 2 |
| Zona 0 | Topo Soft | 1991 | | | 1 |
| Zombie Calavera Prologue | Oscar Toledo Gutiérrez | 2021 | | | 1 |
| ZorricoEX | Physical Dreams | 2022 | | | 3 |